MannanPRO®
Our Core Material
Dazzeon’s MannanPRO® is a medicinal-grade, high-purity extract derived from the inner gel of aloe vera—free from the toxic aloin.
Our proprietary process efficiently isolates Acemannan, an acetylated mannan polysaccharide with proven clinical benefits, including mucosal repair, antibacterial and anti-inflammatory effects, wound healing, gastrointestinal ulcer mitigation, liver protection, and constipation improvement. Recent studies further indicate its potential to inhibit tumor growth and boost immune responses, supporting its use in cancer prevention and treatment.
Over the past two years, we have refined our in-house purification technology using fully equipped production, quality assessment, and microbial testing laboratories. The final extract is rigorously characterized via nuclear magnetic resonance calibrated against a US Pharmacopeia standard.
Dazzeon’s Technology reaches
90%+ Purity
Peerless in the world
Why Dazzeon Biotech?
| Company | Extraction Process | Acemannan Purity | Quality Notes |
|---|---|---|---|
| DAZZEON® (Taiwan) | Proprietary extraction technology — delivers ultra-high purity | Achieves ≥ 110 kDa, ＞ 90 % polysaccharides (Acemannan) | The only large-scale GMP-compliant extraction process in the world; produces pharmaceutical-grade “MannanRx™”, aloin-free, stability ＞ 2 years |
| Brand N (Costa Rica) | Ethanol precipitation & freeze-drying — uncontrolled, broad MW distribution | Top-grade yield 65 %; also offers a 20–25 % grade | Full-spectrum (deleterious matrix effects); uses hand-filleted gel only; shelf-life ＞ 5 years |
| Brand A (USA) | Aseptic processing & low-temperature drying — patented; stabilises ≥ 10 % polysaccharides | ~ 10 % (full spectrum) | Commodity-grade aloe; emphasises batch-scale consistency; polysaccharide range centred on 50–200 kDa |
| Generic Chinese suppliers / researchers | Highly variable: solvent extraction, enzyme-assisted methods, or simple dehydration | ＜ 5 % to ~ 95 %, depending on product | Lower-end products may be mislabelled or degraded (some test only for “aloe polysaccharide”); a few offer ＞ 90 % research-grade. Widely varying standards demand rigorous QC. |
Commercial
- High Price
- Prone to clumping
- Coloration due to impurities
MannanPRO®
- Scalable Production
- Medicine-Grade
- High Safety
- High Stability
- Ensured Activity
- NMR Characterized
2 years of stability and counting
Aloe Vera Applications
Acemannan Published Applications
Immunomodulation & antiviral
Biomaterials and Drug Delivery
Veterinary Cancer Adjuvant
MannanPRO® increases expression of genes related to alcohol addiction inhibition
X
Co-analysis of 14,545 genes and their related pathways (via high-throughput sequencing)
Alcohol-induced liver cell stress
MannanPRO® as a prebiotic reduces opportunistic microbiota population while supporting the growth of beneficial gut flora
X
Population Fold Change
MannanPRO® accelerates human keratinocytes (HaCaT) renewal and strengthens the skin barrier
X
INCI Cosmetic Reg. No.: 39405
Cosmetic Safety and Efficacy Tests
- Eye Sensitization Test
- Skin Sensitization Test
- Non-toxicity Safety Test
- Cosmetic Safety and Efficacy Tests
- Anti-Wrinkle Test
- Anti-Aging Test
- Anti-Inflammatory Test
MannanPRO® repairs the gastric mucosa, resisting gastric acid erosion and reducing Shay’s Ulcers damage
X
Shay’s Ulcers
Nanomerized MannanPRO® can be used as a biocompatible hydrogel drug delivery system
X
MannanPRO® works as an ROS-driven ferroptosis anticancer agent in colorectal cancer cells
X
HC116 Cells
